BIOS E-30 Epigenetics and Gene Regulation
Spring Term 2017 CRN 24705
This course is designed to introduce students to the concept of epigenetics and how it regulates gene expression and heritable phenotypes without changes in the underlying DNA sequence. The first phase is a thorough mechanistic overview with discussion topics including DNA methylation, histone modifications, chromatin remodeling, and non-coding RNAs, as well as the key players that regulate these processes. In the second phase, we cover molecular techniques and model organisms used commonly in epigenetics research. Finally, students apply their knowledge to understand the epigenetic basis of various developmental disorders, the natural aging process, environmental exposures, and relevant human diseases such as tumorigenesis, obesity, neurological disorders, and infections. Readings from recent primary literature/review articles, active class discussion, handouts, and visual materials are used and assignments include hands-on analyses exercises, a mock research proposal, and a final research project.